Thrombin‐Loaded Magnetic Microbubbles for the Treatment of Pseudoaneurysms

The drive toward minimally invasive surgery has yielded multiple benefits for patients but also increased the incidence of pseudoaneurysms (PSA). current standard care is ultrasound-guided thrombin injection to coagulate blood in PSA sac and seal ruptured vessel. There is, however, a risk downstream thrombosis if escapes into communicating vessel this limits patient eligibility injection. In study, feasibility using magnetic targeting reduce distal investigated. Thrombin-loaded microbubbles are formulated injected tissue-mimicking phantoms PSAs with different geometries either saline or whole (equine) blood. Ultrasound imaging used quantify concentration bubbles remaining without application custom-built array. An absorbance-based assay escaping from sac. Magnetic enables significant increase retention all femoral artery models except one, up 97% ± 2.5% being retained. It confirmed that enzymatic activity maintained, clot formation can be successfully achieved